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Japanese Journal of Clinical Oncology 13:335-342 (1983)
© 1983 Foundation for Promotion of Cancer Research

research-article

Induction of Suppressor T Cells by Anti-Globoside Antibodies in Cancer Sera

RITSUKO NOGUCHI, M.D., NORIAKI SHINOMIYA, M.D, KATSUTAKA NAGAI, Ph.D.* and JUNICHI YATA, M.D.

Department of Pediatrics, School of Medicine, Tokyo Medical and Dental University
*Department of Biochemistry. School of Medicine, Tokyo University

Reprint requests: Ritsuko Noguchi, M.D., Department of Pediatrics, School of Medicine, Tokyo Medical and Dental University, 5-45, Yushima 1-chome, Bunkyo-ku, Tokyo 113.

Received January 13, 1983; T cells treated with cancer sera frequently suppressed immunoglobulin production by autologous lymphocytes stimulated with pokeweed mitogen. Sera from healthy individuals did not induce suppressor activity. This suppression is not caused by TG cells (T cells bearing receptors for the Fc portion of immunoglobulin G [IgG]) interacting with immune complexes, because we used T cells depleted of TG cells. The suppressor-inducing factors were separated into an IgG-containing fraction and a fraction with a smaller molecular weight. IgG fractions from all sera that were positive for anti-globoside antibody induced suppressor T cells, and elimination of the anti-globoside antibody from these IgG fractions reduced the ability to induce suppressor T cells. T cells treated with rabbit anti-globoside antiserum also activated suppressor T cells. These observations indicate that the antibodies directed to the globoside antigen on suppressor T cells stimulate the suppressor T cells, and that anti-globoside antibody in cancer sera may play a role in causing immunodeficiency in cancer patients.

Key Words: Suppressor T cells • Cancer sera • Anti-globoside antibody


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