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Japanese Journal of Clinical Oncology 13:425-434 (1983)
© 1983 Foundation for Promotion of Cancer Research

research-article

In Vivo Antitumor Activity of Neocarzinostatin (NCS)-Tumor Antibody Conjugate against a Transplantable Human Leukemia Cell Line (BALL-1)

IKURO KIMURA, M.D., TERUHIKO TSUBOTA, M.D., TAISUKE OHNOSHI, M.D., YUJI SATO, M.D., MORIHIRO OKAZAKI, M.D., YUICHI MANABE, M.D. and SHUINJI ABE, M.D.

Department of Medicine, Okayama University Medical School Okayama

Reprint requests: Ikuro Kimura, M.D., Professor, Department of Medicine, Okayama University Medical School, 2-5-1 Shikata-cho, Okayama 700, Japan.

Received June 4, 1983; The in vivo antitumor activity of NCS-immune immunoglobulin G (IgG) [Neocarzinostatin (NCS) conjugated with rabbit IgG antibody against a human leukemia cell line (NALL-1)] was evaluated in immunosuppressed newborn Syrian hamsters into which a transplantable human leukemia cell line, BALL-1 was implanted. After intraperitoneaJ (i.p.) injection of the conjugate, hamsters preinoculated i.p. with BALL-1 cells survived longer than hamsters treated with control solutions (p < 0.01). The control solutions were NCS, immune IgG, a mixture of NCS and immune IgG, NCS-normal IgG conjugate and physiological saline. There was no change in body weight in the NCS-immune IgG-treated hamsters. The growth of subcutaneously (s.c.) implanted BALL-1 tumors was also inhibited by i.p. administration of NCS-immune IgG; however, the degree of inhibition was not significantly different from that obtained by administration of NCS alone, a mixture of NCS and immune IgG or NCS-normal IgG conjugate. These results indicate that NCS-immune IgG was effective against i.p. BALL-1 tumors, but was less effective against s.c. implanted tumors.


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