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Japanese Journal of Clinical Oncology 16:199-202 (1986)
© 1986 Foundation for Promotion of Cancer Research

research-article

Oncogenes and a Specific Chromosomal Abnormality Associated With Small-Cell Lung Cancers

YOICHI TAYA, Ph.D.

Biology Division, National Cancer Center Research institute Tokyo

Reprint requests: Yoichi Taya, Ph.D., 1-1, Tsukiji 5-chome, Chuo-ku, Tokyo 104, Japan.

Received July 4, 1986; Studies on oncogenes and a specific chromosomal abnormality involved in small-cell lung cancers are reviewed. Amplification and/or expression of one of the three myc family oncogenes (c-myc, N-myc, L-myc) were found in 21 of 31 small-cell lung cancers. However, oncogenes were not detected in DNAs of small-cell lung cancers by the NIH3T3 transfection assay. In addition, a specific deletion on the short arm of chromosome number 3 was often associated with small-cell lung cancers. These characteristics are quite different from those of non-small-cell lung cancers.


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