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Japanese Journal of Clinical Oncology 16:203-212 (1986)
© 1986 Foundation for Promotion of Cancer Research

research-article

Changes in Cell Characteristics Due to Culture Conditions in Cell Lines From Human Small Cell Lung Cancer

TAKEO TERASAKI, Ph.D., YUKIO SHISMOSATO, M.D., TAKASHI NAKAJIMA, M.D., MASARU TSUMURAYA, B.Sc, SHOJIROH MORINAGA, M.D., SETSUO HIROHASHI, M.D., KEN YAMAGUCHI, M.D.1, KANEFUSA KATO, M.D.2, HIROSHI ICHINOSR, M.Sc3 and TOSHIHARU NAGATSU, M.D.3

Pathology, National Cancer Center Research Institute Tokyo
1Endocrinology Divisions, National Cancer Center Research Institute Tokyo
2Department of Biochemistry, Institute for Developmental Research Aichi Prefectural Colony, Kasugai
3Department of Biochemistry,Nagoya University School of Medicine Nagoya

Reprint requests: Takeo Terasaki, Ph.D., Pathology Division, National Cancer Center Research Institute, 5-1-1, Tsukiji, Chuo-ku, Tokyo 104, Japan.

Received June 21, 1986; Eight cultured cell lines were established from human small cell lung cancers. Every cell line showed the morphological and biochemical characteristics of small cell cancer. Changes in cell characteristics were observed in many of these cell lines when culture conditions were changed: "oat cell type" changed to "intermediate cell type" and vice versa when serum-free medium was changed to serum-supplemented medium; a deficiency of vitamin A in the medium caused a change to squamous cells and vice versa; and a tumor promoter (teleocidin B) enhanced the adherence of these cells to the surface of plastic culture dishes. These findings provide evidence that many small cell lung cancer cell lines can change their morphology with changes in the environment of the cells.

Key Words: Small cell lung carcinoma • Cell lines • Morphology • Vitamin A • Telecidin B


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