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Japanese Journal of Clinical Oncology 16:223-233 (1986)
© 1986 Foundation for Promotion of Cancer Research

research-article

Immunohistochemical Study of Small Cell Lung Carcinoma; With Special Reference to the Neuroendocrine Markers Aromatic L-Amino Acid Decarboxylase and Gastrin-Releasing Peptide

TAKASHI NAKAJIMA, M.D.1,, YUKIO SHIMOSATO, M.D.1, SHOJIROH MORINAGA, M.D.1, TAKEO TERASAKI, M.D.1, MASARU TSUMURAYA1, KEN YAMAGUCHI2, HIROSHI ICHINOSE3, TOSHIHARU NAGATSU3, KANEFUSA KATO, M.D.4 and YOICHI NAKAZATO, M.D.5

1Pathology Tokyo
2Endocrinology Divisions, National Cancer Center Research Institute Tokyo
3Department of Bichemistry, Nagoya University School of Medicine Nagoya
4Department of Biochemistry, Institute for Developmental Research Aichi Prefectural Colony, Kasugai
5Department of Pathology Gunma University School of Medicine Maebashi

Reprint requests: Takashi Nakajima, M.D., Pathology Division, National Cancer Center Research Institute, 5-1-1, Tsukiji, Chuo-ku, Tokyo 104, Japan.

Received July 15, 1986; Forty-seven surgically resected small cell lung carcinomas (SCLC) were immunohistochemically studied by using antibodies to various neuroendocrine and epithelial markers. SCLC was shown to be subdivided into two categories, with and without the immunoreactive neuroendocrine markers aromatic L-amino acid decarboxylase, gastrin-releasing peptide, serotonin, chromogranin A and neurofilament protein. Neuron-specific enolase (NSE) and creatine kinase BB isoenzyme (CK-BB), which are also considered to be neuroendocrine markers, had a tendency to be widely distributed in the SCLC with a neuroendocrine marker, but the immunoreactivity for both NSE and CK-BB varied in the SCLC without neuroendocrine markers. Therefore they were not included in the classification. Epithelial markers keratin, involucrin and epithelial membrane antigen were frequently observed in the SCLC with neuroendocrine markers, but less so in the SCLC without neuroendocrine markers. The data are discussed briefly in relation to "classic and variant" forms of SCLC in vitro and to a re cently proposed histological classification of SCLC.

Key Words: Small cell lung carcinoma • Immunohistochemistry • Aromatic L-amino acid decarboxylase • Gastrin-releasing peptide • Keratin • Involucrin


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