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Japanese Journal of Clinical Oncology 16:235-241 (1986)
© 1986 Foundation for Promotion of Cancer Research

research-article

Peptide Hormone Production in Small Cell Lung Carcinomas with Particular Reference to Gastrin-Releasing Peptide

KEN YAMAGUCHI, M.D., KAORU ABE, M.D., ISAMU ADACHI, M.D., KOTOMI OTSUBO, B.S., KOICHI NAGASAKI, B.S., MASAFUMI SUZUKI, M.D., KANAME MARUNO, M.D., FUMIKI ASANUMA, M.D., TAKAYUKI TSUCHIHASHI, M.D., YOSHIO MIYAKE, M.D., KEIGO YOSHINAGA, M.D., HIDEKI MATSUBARA, M.D., KOICHI IMANISHI, M.D., SATOSHI KIMURA, M.D.1, TETSURO KODAMA, M.D.2, TORU KAMEYA, M.D.3 and YUKIO SHIMOSATO, M.D.4

Endocrinology, National Cancer Center Research InstituteTokyo
4Endocrinology Divisions, National Cancer Center Research InstituteTokyo
1Department of Infectious Disease and Applied Immunology, InstItute of Medical Science, University of Tokyo Tokyo
2Department of Internal Medicine, National Matsudo Hospital, Matsudo Chiba
3Department of Pathology School of Medicine Kitasato University Sagamihara, Kanagawa

Reprint requests: Ken Yamaguchi, M.D., Endocrinology Division, National Cancer Center Research Institute, 1-1, Tsukiji 5-chome, Chuo-ku, Tokyo 104, Japan.

Received July 8, 1986; Tissues of 50 small cell lung carcinomas were examined for production of 17 peptide hormones. Only when the concentration of a peptide detected in the tumor was 10 pmol or more per g wet weight, was the peptide considered to be produced by the tumor. The frequency of production of at least one of these peptide hormones was 84%, and that of two or more hormones was 50%. These results indicate that peptide hormone production is a very common phenomenon in small cell lung carcinoma. Of the peptide hormones examined, gastrin-re leasing peptide is produced with the highest frequency, suggesting that this pep- tide could play an important role in small cell lung carcinoma.


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