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Japanese Journal of Clinical Oncology 16:309-315 (1986)
© 1986 Foundation for Promotion of Cancer Research

research-article

Long-Term Survival in Patients with Small Cell Lung Cancer

JUNJI SUGA, M.D.1, NAGAHIRO SAIJO, M.D.1,, TETSU SHINKAI, M.D.1, KENJI EGUCHI, M.D.1, YASUTSUNA SASAKI, M.D.1, TOMOHIDE TAMURA, M.D.1, MASANORI SAKURAI, M.D.1, TETSURO SANO, M.D.1, RYOSUKE ONO, M.D.2, HIDENOBU TAKAHASHI, M.D.3, HIDEHIKO NAKANO, M.D.3, KAZUHIKO NAKAGAWA, M.D.3, AKIO HOSHI, Ph.D.3 and JAMES R. JETT, M.D.4

1Department of Internal Medicine, National Cancer Center Hospital Tokyo
2Department Division, National Cancer Center Hospital Tokyo
3Pharmacology Division, National Cancer Center Research Institute Tokyo
4Mayo Clinic Rochester, Minnesota

Reprint requests: Nagahiro Saijo, M.D., Department of Internal Medicine, National Cancer Center Hospital, 1-1, Tsukiji 5-chome, Chuo-ku, Tokyo 104, Japan.

Received June 23, 1986; Of the 66 patients with small cell lung cancer (SCLC) who were treated by combination chemotherapy with or without radiation therapy from July 1978 to December 1983 at the National Cancer Center Hospital, Tokyo, 12 (18%) sur vived over two years and nine (14%) have remained disease-free over three years. The two-year survival rates were compared according to the patient characteristics of sex, performance status (PS), extent of disease, histologic subtype, regimen of the initial chemotherapy and response to treatment. Sex, extent of disease and response to the initial chemotherapy were the most important prognostic factors. The prognosis for patients with liver or bone metas tasis was poor. All disease-free survivors, except for two patients who were treated by surgical resection after chemotherapy, achieved complete response (CR) with chemotherapy with or without radiation therapy. Eleven of the 12 two-year survivors achieved CR. Because of the small number of patients in our study, it will be necessary to evaluate further the influence of prognostic factors in patients with SCLC in future studies.


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