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Japanese Journal of Clinical Oncology 19:229-236 (1989)
© 1989 Foundation for Promotion of Cancer Research

research-article

Lymphocyte Subsets in Pulmonary Venous and Arterial Blood of Lung Cancer Patients

Yuichi Sato1,*, Kiyoshi Mukai1, Shaw Watanabe2, Masahiro Gotoh1, Yoshihiro Matsuno1, Shuichiroh Furuya1 and Yukio Shimosato1

1Pathology Divisions, National Cancer Center Research Institute 1-1, Tsukiji 5-chome, Chuoku, Tokyo 104
2Epidemiology Divisions, National Cancer Center Research Institute 1-1, Tsukiji 5-chome, Chuoku, Tokyo 104

*For reprints and all correspondence

Received November 18, 1988; accepted May 18, 1989

Lymphocyte subsets in pulmonary venous blood (PVB) smears from 42 patients with lung cancer were immunocytochemically determined. In four patients, pulmonary arterial blood (PAB) smears were also studied for comparison with PVB. Seven healthy donor peripheral blood (PAB) smears were used as controls. The percentage of T cells, helper/inducer T (Th) cells and B cells were significantly lower (P<<0.0l) than in normal controls but those of suppressor/cytotoxic T (Ts) cells, natural killer (NK) cells (P<0.01) and S100+ small lymphoid cells (P<0.05) were higher. This resulted in a decrease in the Th:Ts value in cancer patients (1.46 vs. 2.28 for normal con trols; P<0.01). The Th and Ts value of PVB from patients in pathological Stages III and IV was lower than from those in Stages I and II because of the increase in Ts cells in the former (P<0.05). S100+ small lymphoid cells were increased in cancer patients, especially in those with adenocarcinoma. The present study demonstrates immunoregulation abnormalities in cancer bearing hosts, the results correlating well with the stage of the cancer. Determining lymphocyte subset alterations in PVB did not, however, enable us to detect the changes associated with local immune responses against cancer.

Key Words: Lung cancer • Pulmoanry venous blood • Lymphocyte subpopulations • Immuno cytochemistry • Antitumor immunity


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