Skip Navigation

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Request Permissions
Google Scholar
Right arrow Articles by Arima, S.
Right arrow Articles by Shimura, H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Arima, S.
Right arrow Articles by Shimura, H.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Japanese Journal of Clinical Oncology 19:237-241 (1989)
© 1989 Foundation for Promotion of Cancer Research

research-article

Distributions of Tegafur in Tissues of Gastric Adenocarcinoma Patients: Tissue Uptakes and Concentrations in Plasma after Oral and Rectal Administrations

Sumitaka Arima1,*, Kitaro Futami1, Shigeaki Yoshimura1 and Hidehiko Shimura2

1Department of Surgery, Chikushi Hospital, School of Medicine Fukuoka University, 337-1 Zokumyoin Chikushino, Fukuoka 818
2First Department of Surgery, School of Medicine, Fukuoka University Fukuoka, 814-01

*For reprints and all correspondence

Received July 22, 1988; accepted February 13, 1989

Fifty-one gastric adenocarcinoma patients were divided into two groups, according to the route of administration of the anticancer drug. One group was given FT-207 (tegafur, an enteric coated granule) orally and the other group, FT-207 in the form of a suppository. Blood and tissue concentrations of the drug were examined after a three-day administration of 750 mg at 09.00 and 21.00 hours. There were no significant differences between the two groups with respect to the concentrations of FT-207 and its metabolite 5-FU in the tissues. Levels of 5-EU in the excised tumor averaged 0.256 and 0.160 µg/g. in oral and rectal administrations, respectively, and levels in normal lymph nodes averaged 0.174 and 0.179 µg/g respectively. The difference in 5-FU lev els between normal and tumor tissues was statistically significant (P<0.05).

Key Words: Gastric cancer • Tegafur aiid 5-FU distributions • Oral and rectal administrations


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Drug Metab. Dispos.Home page
T. Komatsu, H. Yamazaki, N. Shimada, M. Nakajima, and T. Yokoi
Roles of Cytochromes P450 1A2, 2A6, and 2C8 in 5-Fluorouracil Formation from Tegafur, an Anticancer Prodrug, in Human Liver Microsomes
Drug Metab. Dispos., April 13, 2001; 28(12): 1457 - 1463.
[Abstract] [Full Text]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.