Japanese Journal of Clinical Oncology 19:265-270 (1989)
© 1989 Foundation for Promotion of Cancer Research
research-article |
Prospective Hormone Study of Hypothalamic-Pituitary Function in Patients with Nasopharyngeal Carcinoma after High Dose Irradiation
1Departments of Radiation Oncology 199 Tun-Hwa North Road, Taipei, Taiwan
2Internal Medicine, Chang-Gung Memorial Hospital 199 Tun-Hwa North Road, Taipei, Taiwan
*For reprints and all correspondence
Received October 6, 1988; accepted March 31, 1989
With the aim of evaluating the effect of high dose irradiation (6,500 cGy/36 fractions or higher) to pituitary fossa, a prospective study was carried out in patients with nasopharyngeal cancer by a serial determination of several hormones in the serum, before and after the course of radiation therapy (RT). The radiation treatment field was at least 1 cm above the skull base with bilateral parallel opposing fields. Hormone assays were performed three times on each patient: (1) prior to, (2) one month after, (3) 15–18 months after radiation therapy. The study included determination of serum luteinizing hormone (LH), follicle-stimulating hormone (FSH), thyroid-stimulating hormone (TSH), cortisol, growth hormone (GH) and prolactin concentrations and LH-releasing hormone, thyrotrophin-releasing hormone stimulation and insulin tolerance tests were also carried out. Complete profiles were obtained in 24 patients (16 males and 8 females), aged 16–67 years. The results showed a significant decrease in the level of serum peak value of LH in males 18 months after therapy, and also in GH both one month and 18 months after therapy. A significant increase in the peak value of serum TSH observed after therapy. Decreased serum FSH, cortisol and prolactin levels were noted, but these did not reach statistical significance. The decrease in GH level appeared earlier and was more sensitive than that found for the other hormones, and could prove to be a useful parameter for clinical evaluation. None of the patients showed any clinically recognizable symptoms or signs of hormone deficiency in the 18–33 months following completion of the radiation therapy.
Key Words: Nasopharyngeal carcinoma • Prospective hormone study • Hypothalmo-pituitary hormone • Radiotherapy
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