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Japanese Journal of Clinical Oncology 19:299-304 (1989)
© 1989 Foundation for Promotion of Cancer Research

case-report

Phyllodes Tumor of the Prostate: A Case Report

Hisao Ito1,*, Masanori Ito1, Naoki Mitsuhata2 and Eiichi Tahara1

1Department of Pathology, Hiroshima University School of Medicine 1-2-3, Kasumi, Minami-ku, Hiroshima 734
2Department of Urology, Kure Mutual Aid Hospital 3-28, Nishichuo 2-chome, Kure, Hiroshima 737

*For reprints and all correspondence

Received April 7, 1989; accepted April 27, 1989

A case of prostatic phyllodes tumor which developed in a 78-yr-old man is reported. Histolog ically, the tumor comprised myxomatous and cellular portions with a proliferation of atypical stromal cells. Multinucleated giant cells were occasionally present, but mitoses were rare. Fibroblastic differentiation of the tumor cells was confirmed by numerous rough endoplasmic retic ulums and free ribosomes, and by immunoreactivity for vimentin. Approximately one-third of the tumor cells showed estrogen-receptor immunoreactivity at their nuclei. The patient is well, with no evidence of tumor recurrence, five years after the resection. The tumor was diagnosed as being a benign prostatic phyllodes tumor showing fibroblastic differentiation, and of an estrogen-dependent nature.

Key Words: Phyllodes tumor • Prostate • Immunohistochemistry • Electron microscopy


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