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Japanese Journal of Clinical Oncology 21:325-329 (1991)
© 1991 Foundation for Promotion of Cancer Research

research-article

Deletions and Rearrangements of the Retinoblastoma Gene in Hepatocellular Carcinoma, Insulinoma and Some Neurogenic Tumors as Found in a Study of 121 Tumors

Tsutomu Nakamura1, Yukio Iwamura1,*, Michio Kaneko2, Kunio Nakagawa3, Koichi Kawai4, Keiji Mitamura5, Tsukasa Futagawa1 and Hideo Hayashi1

1Department of Microbiology, Institute of Basic Medical Sciences 1-1 Tennodai 1-chome, Tsukuba 305
2Departments of Pediatric Surgery 1-1 Tennodai 1-chome, Tsukuba 305
3Departments of Neurosurgery 1-1 Tennodai 1-chome, Tsukuba 305
4Departments of Endocrinology, Institute of Clinical Medicine, University of Tsukuba 1-1 Tennodai 1-chome, Tsukuba 305
5Department of Infectious Diseases, Institute of Medical Science, University of Tokyo 6-1, Shiroganedai 4-chome, Minato-ku, Tokyo 108

*For reprints and all correspondence

Received February 19, 1991; accepted May 31, 1991

The retinoblastoma gene (Rb) is one of the tumor suppressor genes to have already been cloned. Deletions and inactivations of the gene have been widely observed in various types of hyman tumor. To study the generality of Rb alteration in human tumors, 121 cases of tumor DNAs were examined for abnormalities in the gene structure by blot hybridization. Deletions of both alleles were detected in hepatocellular carcinoma, insulinoma and neuroblastoma. Rearrangements and allelic deletions of the Rb gene were, moreover, observed in some brain tumors and hepatocellular carcinomas, respectively. All were surgically resected tumors. The observations suggest the inactivation of Rb through structural alterations sometimes to correlated with the development or progression of these types of human tumor.

Key Words: Retinablastoma gene • Hepatocellular carcinoma • Insulinoma • Neuroblastoma


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