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Japanese Journal of Clinical Oncology 21:377-383 (1991)
© 1991 Foundation for Promotion of Cancer Research

case-report

Local Adoptive Immunotherapy Using Lymphokine-activated Killer Cells and Interleukin-2 against Malignant Pleural Mesothelioma: Report of Two Cases

Hiroaki Yanagawa, Saburo Sone*, Katsuyuki Fukuta, Yasuhiko Nishioka and Takeshi Ogura

Third Department of Internal Medicine, School of Medicine, The University of Tokushima Kuramotocho 3, Tokushima 770

*For reprints and all correspondence

Received November 6, 1990; accepted May 30, 1991

Malignant pleural mesothelioma is refractory to conventional therapy. We tried local adoptive immunotherapy using lymphokine-activated killer (LAK) cells and interleukin-2 (IL-2) to control malignant pleural effusion due to mesothelioma in two patients: Case 1 was that of a 69-year-old man, and Case 2 that of a 49-year-old woman with complicating chronic idiopathic thrombocytopenic purpura. A systemic survey revealed no sign of metastasis in either case. Intrapleural instillations of 6.7 x 109 autologous LAK cells in Case 1, or 11.3 x 109 allogeneic LAK cells in Case 2, with daily injections of IL-2 resulted in reductions of the pleural effusions in each case and in a decline in the level of hyaluronic acid in the effusion, in Case 1. The instillations of autologous and allogeneic LAK cells were well tolerated. The results suggest that local adoptive immunotherapy could be useful in the treatment of malignant effusion due to mesothelioma.

Key Words: Malignant mesothelioma • Adoptive immunotherapy • Lymphokine activated killer cells • Interleukin-2-Idiopathic thrombocytopenic purpura


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