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Japanese Journal of Clinical Oncology 21:388-391 (1991)
© 1991 Foundation for Promotion of Cancer Research

case-report

A Case of Thymic Cyst with Elevated Sialylated Lewis X-i, Carbohydrate Antigen 19-9 and Tissue Polypeptide Antigen in the Cystic Fluid. with No Elevation of Serum Tumor Markers

Tetsuro Sano1,*, Shigeru Kuramochi2, Michiko Takahashi3, Fumiki Asanuma1, Yoshinori Yamada1, Kazuo Uesato1, Hajime Toyoda1, Takeshi Miyagawa1, Teruhisa Kurokawa1 and Eiji Kawamura1

1Departments of Surgery 9-1, Shirokane 5-chome, Minato-ku, Tokyo 108
2Internal Medicine, Kitasato Institute Hospital 9-1, Shirokane 5-chome, Minato-ku, Tokyo 108
3Department of Pathology, Keio University School of Medicine 35 Shinanomachi, Shinjuku-ku, Tokyo 160

*For reprints and all correspondence

Received March 7, 1991; accepted June 16, 1991

A 56-year-old man, tentatively diagnosed as having cardiomegaly, was found to have a large cyst in the left anterior mediastinum. At thoracotomy a multilocular cystic mass containing a colorless serous fluid was found and resected. Histologically, the cyst was lined with flattened epithelial cells, and thymic tissue was present in the cyst's wall; a diagnosis of thymic cyst was made. There were no malignant components or inflammatory changes. Sialylated Lewis X-i (SLX), carbohydrate antigen 19-9 (CA19-9) and tissue polypeptide antigen (TPA) in the cystic fluid were markedly elevated, while the serum concentrations of these tumor markers were within the normal ranges. Immunohistochemical studies showed the epithelial cells lining the cyst to contain CA19-9 and SLX. The findings suggest the tumor markers to have originated in the thymic epithelium lining the cyst.

Key Words: Thymic cyst • Sialylated Lewis X-i • Carbohydrate antigen 19-9 • Tissue polypeptide antigen


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