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Japanese Journal of Clinical Oncology 26:189-193 (1996)
© 1996 Foundation for Promotion of Cancer Research

Retropharyngeal Abscess after Radiation Therapy and Cis-platinum, 5-Fluorouracil Treatment for Nasopharyngeal Carcinoma with Collagen Disease: Report of Two Patients and a Review of the Literature

Masato Hareyama1,, Hisayasu Nagakura1, Mitsuharu Tamakawa1, Kazusa Hyodo1, Kohji Asakura2, Takashi Horikoshi3, Shigemichi Tanaka4, Kohzoh Imai5, Atsuo Hattori6, Atsushi Oouchi1, Mitsuo Shido1, Hirofumi Koshiba1, Koh-ichi Sakata1 and Kazuo Morita1

1 Department of Radiology, Sapporo Medical University Sapporo
2 Department of Otolaryngology, Sapporo Medical University Sapporo
3 Department of Dermatology, Sapporo Medical University Sapporo
4 Department of Internal Medicine (Section 2), Sapporo Medical University Sapporo
5 Department of Internal Medicine (Section 1), Sapporo Medical University Sapporo
6 Department of Internal Medicine (Section 1), Sapporo Medical University Sapporo

For reprints and all correspondence: Masato Hareyama, Department of Radiology, Sapporo Medical University, South-1, West-16, Chuo-ku, Sapporo 060

Received October 6, 1995; accepted January 18, 1996

Collagen disease are frequently associated with malignant tumors. Recently, radiotherapy combined with chemotherapy has been recommended for improving the efficacy of treatment for nasopharyngeal carcinoma. Two patients with nasopharyngeal carcinoma complicated by collagen diseases (dermatomyositis in one, and Sjögren's syndrome with mixed connective tissue disease in the other) were given radiotherapy combined with chemotherapy consisting of cis-platinum and 5-fluorouracil. Following this combination therapy, both patients developed retropharyngeal abscess and ulceration of the mucosal membrane on the posterior wall of the oropharynx; there was no tumor cell involvement. Because these injuries were more severe than would have been expected from radiotherapy alone, it is recommended that special attention be paid to combination therapy in patients with nasopharyngeal carcinoma complicated by collagen disease.

Key Words: Nasopharyngeal carcinoma • Collagen disease • Radiotherapy • Chemotherapy • Complications


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