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Japanese Journal of Clinical Oncology, Vol 27, Issue 3 193-196, Copyright © 1997 by Foundation for Promotion of Cancer Research

ORIGINAL ARTICLE

Papillary adenocarcinoma of the sigmoid colon associated with psammoma bodies and hyaline globules: report of a case

H Nakayama, T Okumichi, S Nakashima, A Kimura, M Ikeda and H Kajihara
First Department of Pathology, Kochi Medical School, Japan.

We report a case of papillary adenocarcinoma of the sigmoid colon with psammoma bodies and intracytoplasmic hyaline globules. The patient was a 59-year-old woman. The tumor showed central ulceration with smooth elevated ridges. Histologically, the tumor was composed of numerous large irregular tubular structures accompanying infolded papillary growth. The tumor cells showed cytoplasmic basophilia and prominent nuclear atypia. Psammomatous-type calcification was scattered in the tumor stroma as well as in the glandular lumina. In addition, intracytoplasmic hyaline globules of various sizes were seen in the neoplastic cells. We propose the name papillary adenocarcinoma associated with psammoma bodies and hyaline globules for this tumor. Accumulation of further cases is needed to clarify the clinical significance of this type of tumor.
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