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Japanese Journal of Clinical Oncology, Vol 27, Issue 6 445-446, Copyright © 1997 by Foundation for Promotion of Cancer Research

CASE REPORTS

A re-analysis of a randomized clinical trial for gastric cancer using interval censoring

J Sakamoto, S Teramukai, H Nakazato and Y Ohashi
Department of Surgery, Aichi Prefectural Hospital, Japan.

In a previous randomized clinical trial against curatively resected gastric cancer, we compared the effect of immunochemotherapy to chemotherapy and obtained significantly better survival and disease-free survival time (DFS) in a combined therapy group. Although DFS was analysed with a conventional approach in which the onset of relapse was defined as the diagnosis of relapse, we considered it necessary to re-analyse the data and compare the results of an interval-censored approach with the conventional approach, in order to examine whether the conclusion might be altered depending on the approach.
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J. Sakamoto and S. Teramukai
Data Handling in Cancer Clinical Trials--How We Can Minimize Potential Biases
Jpn. J. Clin. Oncol., January 1, 2002; 32(1): 1 - 2.
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