Japanese Journal of Clinical Oncology, Vol 28, Issue 1 5-11, Copyright © 1998 by Foundation for Promotion of Cancer Research
H Tsuda, C Sakamaki, S Tsugane, T Fukutomi and S Hirohashi
The histological grade of atypia is a known prognostic indicator for breast
cancer patients and correlates with many gene and chromosome alterations.
To investigate the independent prognostic significance of gene and
chromosome alterations in axillary node-negative (n0) breast cancers of the
invasive ductal and invasive lobular types, the prevalence of eight gene
and chromosome alterations and their association with histological grade
and recurrence was studied in 129 consecutive patients who had undergone
resection over an average follow-up period of 43.4 months. Loss of
heterozygosity on 16q, 17p, 16p, 17q and 18q, p53 gene mutation and
c-erbB-2 and int-2 gene amplifications were detected in 55%, 37%, 25%, 24%,
22%, 23%, 15% and 11% respectively. Individual alterations in 17p, 17q,
18q, c-erbB-2 and p53 were detected most frequently and gene and chromosome
alterations tended to be accumulated in Grade 3 n0 invasive ductal/lobular
carcinomas. Histological grade, 18q, int-2 and the number of these gene and
chromosome alterations were significant prognostic indicators on Cox's
univariate proportional hazard model, and 18q and int-2 were still
significant after adjustment for histological grade. Results suggested that
examination of the presence of certain gene and chromosome alterations, as
well as histological grade, were effective in identifying n0 breast cancer
patients at high risk of early recurrence.
ORIGINAL ARTICLE
Prognostic significance of accumulation of gene and chromosome alterations and histological grade in node-negative breast carcinoma
Pathology Division, National Cancer Center Research Institute and Hospital, Tokyo, Japan.
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