Japanese Journal of Clinical Oncology, Vol 28, Issue 11 657-660, Copyright © 1998 by Foundation for Promotion of Cancer Research
M Murata, T Shiraishi, K Fukutome, M Watanabe, M Nagao, Y Kubota, H Ito, J Kawamura and R Yatani
BACKGROUND: The p53 mutation spectrum of prostate cancers developing in
Japan indicates a role for environmental factors. This suggests there might
be differences in susceptibility due to genetic polymorphisms in metabolic
activation enzyme genes. We analyzed genetic polymorphisms of the
xenobiotic-metabolizing enzymes, CYP1A1 and GSTM1. METHOD: Genotyping of
CYP1A1 and GSTM1 was investigated by using allele-specific PCR in 115
prostate cancer (PCa) patients and 204 control patients. RESULTS: The
CYP1A1 Val/Val genotype significantly increased the risk for PCa (OR = 2.6;
95% CI = 1.11-6.25) and the Ile/Val genotype showed a similar tendency (OR
= 1.4; CI = 0.86-2.29). Individuals with the GSTM1 (0/0) genotype
demonstrated a slightly increased risk (OR = 1.3; CI = 0.82-2.04). The
combination of the CYP1A1 Val allele and GSTM1 (0/0) genotype was
associated with a higher risk (OR = 2.3; CI = 1.18-4.48) than the CYP1A1
Val allele alone. When cases were analyzed by age at initial diagnosis, the
relative risks with both the CYP1A1 Val allele and the GSTM1 (0/0) genotype
were higher in the young group than in the old group (CYP1A1; OR = 1.7, CI
= 0.89-3.17: GSTM1; OR = 1.6, CI = 0.84-2.99). The frequency of the GSTM1
(0/0) genotype was also higher in patients with advanced stage disease. In
stage D, the OR was 1.7 with a CI of 0.93-3.17 and in stages A and B, the
OR was 0.8 with a CI of 0.40-1.62. CONCLUSIONS: These results suggest that
CYP1A1 and GSTM1 polymorphisms are linked to a propensity for PCa
development.
ORIGINAL ARTICLE
Cytochrome P4501A1 and glutathione S-transferase M1 genotypes as risk factors for prostate cancer in Japan
Department of Urology, Mie University School of Medicine, Tsu, Japan. muratama@doc.medic.mie-u.ac.jp
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