Japanese Journal of Clinical Oncology, Vol 28, Issue 6 360-363, Copyright © 1998 by Foundation for Promotion of Cancer Research
M Onozawa, K Fukuda, M Ohtani, H Akaza, T Sugimura and K Wakabayashi
BACKGROUND: Epidemiological studies have suggested that soybean isoflavones
are associated with a lower risk of prostate cancer. However, the
mechanisms of prostate cancer prevention by soybean isoflavones have yet to
be fully clarified. METHODS: Two soybean isoflavones (genistein and
daidzein) and their glucosides (genistin and daidzin) were tested for their
effects on cell growth and apoptosis of the LNCaP human prostatic cancer
cell line. RESULTS: Among these isoflavones, genistein was found to inhibit
the growth of LNCaP most effectively, with an IC50 value of 40 microM. The
inhibition of cell growth by genistein was accompanied by the suppression
of DNA synthesis and the induction of apoptosis. Expression of
prostate-specific antigen (PSA) in LNCaP was also significantly reduced by
the treatment with genistein. CONCLUSIONS: The results suggest that
genistein might primarily influence human prostate cancer development by
reducing tumor growth.
ORIGINAL ARTICLE
Effects of soybean isoflavones on cell growth and apoptosis of the human prostatic cancer cell line LNCaP
Cancer Prevention Division, National Cancer Center Research Institute, Tokyo, Japan.
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