Japanese Journal of Clinical Oncology, Vol 29, Issue 10 467-473, Copyright © 1999 by Foundation for Promotion of Cancer Research
M Kawashima, T Ogino, H Fujii, S Ishikura, Y Ito and H Ikeda
BACKGROUND: To estimate the effect of tumor volume on local-regional
control of pharyngolaryngeal cancer by radiotherapy (RT). METHODS:
Definitive RT for 48 patients with squamous cell carcinoma of the lateral
wall of the oropharynx, pyriform sinus and supraglottic larynx was
reviewed. Tumor volume was estimated from computed tomography and it was
expressed as the diameter of a sphere the volume of which is equal to the
primary tumor (Td) and sum of the volumes of metastatic adenopathies (Nd).
All patients received > or =60 Gy (median 66 Gy) to the gross tumor by
conventional fractionation with or without chemotherapy. RESULTS: A median
period of follow-up for survivors was 32.7 months (range, 12.4-68.6). The 2
year local control rate for T1/2 (n = 30) and T3/4 (n = 18) patients was 72
and 65%, respectively (P= 0.966), however, the rates for Td < 4 cm
tumors (n = 37) and Td > or = 4 cm tumors (n = 11) were significantly
different (80% vs 27%, P < 0.001). The 2 year regional control rates for
Nd < 3 cm lesions (n = 29) and Nd > or = 3 cm (n = 19) lesions were
85 and 42%, respectively (P < 0.001). The 2 year ultimate regional
control rates for N2/3 disease with Nd < 4 cm (n = 11) and Nd > or =
4 cm (n = 11) were 100 and 42%, respectively (P = 0.004). CONCLUSIONS:
Conventional radiotherapy may allow organ preservation and ultimate local
control in patients with Td < 4 cm and Nd < 4 cm disease, but larger
volume tumors should be considered candidates for the most intensive
chemoradiotherapy.
CASE REPORTS
Local-regional control by conventional radiotherapy according to tumor volume in patients with squamous cell carcinoma of the pharyngolarynx
Department of Radiology, National Cancer Center Hospital East, Kashiwa, Chiba, Japan. mkawashi@east.ncc.go.jp
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  M. Kawashima, R. Hayashi, M. Tahara, M. Yamazaki, M. Miyazaki, S. Arahira, and T. Ogino Accelerated Radiotherapy and Larynx Preservation in Favorable-risk Patients with T2 or Worse Hypopharyngeal Cancer Jpn. J. Clin. Oncol., June 21, 2007; (2007) hym040v1. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. R. Gordon, L. A. Loevner, A. Shukla-Dave, R. O. Redfern, A. I. Sonners, A. M. Kilger, M. A. Elliott, M. Machtay, R. S. Weber, J. D. Glickson, et al. Intraobserver Variability in the MR Determination of Tumor Volume in Squamous Cell Carcinoma of the Pharynx AJNR Am. J. Neuroradiol., June 1, 2004; 25(6): 1092 - 1098. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Kawashima, T. Ogino, R. Hayashi, S. Ishikura, K. Nihei, Y. Ito, H. Ikeda, S. Ebihara, and Y. Itai Influence of Postsurgical Residual Tumor Volume on Local Control in Radiotherapy for Maxillary Sinus Cancer Jpn. J. Clin. Oncol., May 1, 2001; 31(5): 195 - 202. [Abstract] [Full Text] [PDF]
|
|