Japanese Journal of Clinical Oncology, Vol 29, Issue 10 490-493, Copyright © 1999 by Foundation for Promotion of Cancer Research
N Hamajima, H Yuasa, K Matsuo and Y Kurobe
BACKGROUND: The detection of gene-environment interaction can provide
important clues not only for resolving biological mechanisms underlying
diseases, but also for disease prevention. The newly introduced case-only
study was compared with traditional case-control study in terms of
statistical power to detect significant gene-environment interaction.
METHODS: Odds ratios for interaction were calculated in the framework of
case-control study and case-only study separately, by an unconditional
logistic model. Hypothetical data with 200 cases and 200 or 400 controls
and real published data derived from four cancer case-control studies of
genotype and smoking were used for the comparisons. RESULTS: Although odds
ratio estimates for interaction were the same, 95% confidence intervals
were narrower in case-only studies than in case-control studies. Similarly,
there were no substantial differences in point estimates for interaction in
four real cancer case-control studies between the two study designs, but
the confidence intervals were narrower with the case-only study.
CONCLUSIONS: Although the case-only study does not provide odds ratios for
exposure or genotype alone, it is very useful for the detection of
interaction, especially for screening purposes.
ORIGINAL ARTICLE
Detection of gene-environment interaction by case-only studies
Division of Epidemiology, Aichi Cancer Center Research Institute, Nagoya, Japan. nhamajim@aichi-cc.pref.aichi.jp
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  L.-Y. Wang and W.-C. Lee Population Stratification Bias in the Case-Only Study for Gene-Environment Interactions Am. J. Epidemiol., July 15, 2008; 168(2): 197 - 201. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C.-X. Yang, K. Matsuo, H. Ito, M. Shinoda, S. Hatooka, K. Hirose, K. Wakai, T. Saito, T. Suzuki, T. Maeda, et al. Gene-environment interactions between alcohol drinking and the MTHFR C677T polymorphism impact on esophageal cancer risk: results of a case-control study in Japan Carcinogenesis, July 1, 2005; 26(7): 1285 - 1290. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Q. Tan, A. I. Yashin, E. M. Bladbjerg, M. P.M. de Maat, K. Andersen-Ranberg, B. Jeune, K. Christensen, and J. W. Vaupel A Case-Only Approach for Assessing Gene by Sex Interaction in Human Longevity J. Gerontol. A Biol. Sci. Med. Sci., April 1, 2002; 57(4): B129 - 133. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. A. Hobbs, M. A. Cleves, and C. J. Simmons Genetic Epidemiology and Congenital Malformations: From the Chromosome to the Crib Arch Pediatr Adolesc Med, April 1, 2002; 156(4): 315 - 320. [Full Text] [PDF]
|
|