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Japanese Journal of Clinical Oncology, Vol 29, Issue 10 504-508, Copyright © 1999 by Foundation for Promotion of Cancer Research

ORIGINAL ARTICLE

Gestational choriocarcinoma whose responsible pregnancy was a complete hydatidiform mole identified by PCR analysis with new sequence tagged site primers

Y Kaneta, R Yoshiyama, N Inagaki, K Toyoshima, K Ito, R Nishino, H Kitai, H Kato, K Asanoma and N Wake
Department of Obstetrics and Gynecology, Social Insurance, Saitama Hospital, Urawa, Japan.

We report a case where the pregnancy responsible for a gestational choriocarcinoma was not the antecedent pregnancy or the second normal term delivery, but a complete hydatidiform mole that had advanced to clinically invasive mole. This responsible pregnancy was identified by polymerase chain reaction analysis (PCR). PCR analysis was performed by using five new sets of sequence-tagged site (STS) primers on four chromosomes (chr. 1, D1S225; chr. 3, D3S1744; chr. 12, D12S1090; chr. 18, D18S849 and D18S877). The constitution of alleles of choriocarcinoma was shown to be almost identical with that of the husband on every marker. The allele patterns of choriocarcinoma on D3S1744 and D12S1090 were not observed with DNA from the patient. The band pattern originating from molar DNA was also identical with those of the husband and choriocarcinomas on D18S849 and D1S225.
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