Japanese Journal of Clinical Oncology, Vol 29, Issue 12 604-607, Copyright © 1999 by Foundation for Promotion of Cancer Research
K Motomura, H Inaji, Y Komoike, T Kasugai, S Noguchi and H Koyama
BACKGROUND: We aimed to evaluate whether dye-guided sentinel node biopsy is
a useful indicator of axillary node involvement in breast cancer patients
and whether clinicopathological features affect its success in identifying
sentinel nodes. METHODS: Sentinel node biopsy was performed in patients
with stage I or II breast cancer using an indocyanin green dye-guided
method. RESULTS: We could identify sentinel nodes in 127 (73.8%) of 172
patients. The mean number of sentinel nodes per patient was 1.7 (range,
1-8) and the mean node size was 9.3 mm (range, 3.0-28.0 mm). Of the 127
patients, 40 (31.5%) also had axillary node involvement. In 16 (40.0%) of
these, the sentinel node was the only node involved. There was concordance
between sentinel node and axillary node status in 122 (96.1%) of the 127
patients. Success in identifying sentinel nodes was not affected by tumor
size, operative procedure, histological type of tumor or tumor location;
however, the success rate was significantly lower in patients with axillary
node involvement (65.7 vs 79.0% in axillary node-negative patients, p =
0.039) and the presence or absence of lymphatic or vascular invasion in the
tumor (63.8 vs 78.9% in patients without lymphatic or vascular invasion, p
= 0.043). Sentinel nodes could also be identified significantly more
frequently in patients under 50 years old (83.3%) than in those over 50
years old (64.8%, p = 0.009). CONCLUSIONS: Sentinel node biopsy guided by
indocyanin green dye is an easy technique with an acceptable success rate
in detecting sentinel nodes and predicting axillary nodal status. Axillary
node status, the presence or absence of lymphatic or vascular invasion in
the tumor and patient age affect its success in identifying sentinel nodes.
ORIGINAL ARTICLE
Sentinel node biopsy guided by indocyanine green dye in breast cancer patients
Department of Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases, Japan.
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