Japanese Journal of Clinical Oncology, Vol 29, Issue 4 187-191, Copyright © 1999 by Foundation for Promotion of Cancer Research
M Kammori, M Kaminishi, K Kobayashi, T Oohara, H Endo, K Takubo and H Hashimoto
BACKGROUND: High levels of urokinase-type plasminogen activator (u-PA) were
demonstrated in gastric carcinomas along with inhibitors of plasminogen
activators (PAI-1 and PAI-2). They may influence the ability to invade and
metastasize and therefore be of importance to the risk of recurrence of
stomach neoplasms after curative operation. This also appears to be the
case for p53 mutations and p53 protein overexpression. METHODS: Six
patients, all differentiated cancer cases who developed recurrent disease
5-10 years after curative operations for early gastric cancers (recurrence
group), were studied in comparison with 49 patients who had no recurrence
more than 10 years after similar surgery (control group). The expression of
u-PA, PAI-1, PAI-2 and p53 was compared immunohistochemically in the
recurrence and control groups. RESULTS: The expression of PAI-2 was
significantly more frequent in the recurrence group, being found in five
(83.3%) patients vs eight (16.3%) in the control group. p53 was expressed
in five (83.3%) patients in the recurrence group and in 15 (30.6%) in the
control group; the rate was again significantly higher in the former.
CONCLUSION: The results suggest that PAI-2 and p53 expressed in
differentiated early gastric cancers are possible indices of the risk of
recurrence.
ORIGINAL ARTICLE
Immunohistochemical analysis of PAI-2 (plasminogen activator inhibitor type 2) and p53 protein in early gastric cancer patients with recurrence: a preliminary report
Department of Surgery, University of Tokyo Branch Hospital, Japan. kammori-dis@h.u-tokyo.ac.jp
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