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Japanese Journal of Clinical Oncology 30:571-573 (2000)
© 2000 Foundation for Promotion of Cancer Research

Two Cases of Non-Hodgkin’s Lymphoma in First Degree Relatives

Itsuro Ota, Kenji Shinohara, Kazuhiko Muraki, Naofumi Fukuda, Toru Takahashi, Ryohei Nawata and Yoko Shimohakamada+,§

Division of Hematology, Department of Medicine, Yamaguchi Prefecture Central Hospital, Hofu, Japan

Two cases of non-Hodgkin’s lymphoma (NHL) generated within 6 months in first degree relatives, a father and a son, are presented. The NHL was a diffuse large B-cell type in the father and a small cleaved follicular type in the son. Cytogenetic and molecular studies of the lymphoma cells revealed the rearrangement of the immunoglobulin heavy chain (JH) gene in both patients, the mutation of p53 gene in the father and t(14; 18) (q32; q21) in the son. Both patients had low serum immunoglobulin levels. It is not known whether the occurrence of NHL in this family was incidental or pathogenetically related, since there was no clear common molecular abnormality between the father and the son. The pathogenetic mechanism of this familial occurrence of NHL is discussed.

+ For reprints and all correspondence: Kenji Shinohara, Division of Hematology, Department of Medicine, Yamaguchi Prefecture Central Hospital, Hofu 747-8511, Japan

§ Abbreviations: NHL, non-Hodgkin’s lymphoma; HD, Hodgkin’s disease; Ig, immunoglobulin; IgH (JH), immunoglobulin heavy chain; IL, interleukin; FRR, familial relative risk


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