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Japanese Journal of Clinical Oncology 30:105-108 (2000)
© 2000 Foundation for Promotion of Cancer Research

Simultaneous Development of a Pineal Tumor and an Intradural Spinal Mass During Remission of Acute Lymphocytic Leukemia

Tooru Kudoh1, Hideto Otoi1, Nobuhiro Suzuki1, Takanori Oda1, Shizue Katoh1, Hidenari Akiba2, Masato Hareyama2 and Shunzo Chiba1,+

Departments of 1Pediatrics and 2Radiology, School of Medicine, Sapporo Medical University, Sapporo, Japan

A small percentage of children with acute lymphocytic leukemia experience relapse in the central nervous system in spite of prophylaxis. Diffuse leptomeningeal infiltration is common but an intracranial leukemic mass or spinal cord involvement is a rare manifestation. We report a child with acute lymphocytic leukemia who simultaneously developed a pineal tumor and an intradural spinal cord mass as her first relapse. She was successfully managed by comprehensive combined treatment including peripheral blood stem cell transplantation. She remains in continuous complete remission for more than 5 years without further evidence of neurological sequelae.

+ For reprints and all correspondence: Tooru Kudoh, Department of Pediatrics, School of Medicine, Sapporo Medical University, S1, W16, Chuo-ku, Sapporo, 060-8543, Japan. E-mail: tkudoh@sapmed.ac.jpAbbreviations: CNS, central nervous system; ALL, acute lymphocytic leukemia; WBC, white blood cell; CSF, cerebrospinal fluid; CT, computed tomography; MRI, magnetic resonance imaging; PBSC, peripheral blood stem cell


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