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Japanese Journal of Clinical Oncology 30:109-112 (2000)
© 2000 Foundation for Promotion of Cancer Research

CT-assisted Transbronchial Brachytherapy for Small Peripheral Lung Cancer

Toshiaki Kobayashi1, Masahiro Kaneko1, Minako Sumi2, Kaoru Kubota3 and Haruhiko Kondo4,+

1Endoscopy Division and 2Radiation Oncology Division, National Cancer Center Hospital, Tokyo, 3Division of Thoracic Oncology, National Cancer Center East, Kashiwa, Chiba and 4Thoracic Surgery Division, National Cancer Center Hospital, Tokyo, Japan

Transbronchial brachytherapy for small peripheral lung cancer was developed with the use of the CT-guided bronchoscopy technique. Under CT guidance, an applicator carrying a dummy source was introduced into a lesion and stabilized. A radioactive source was then delivered through the applicator using a high dose rate remote afterloading system. For multiple radiation fractions, a marker was placed immediately under the pleura in a peripheral bronchus penetrating the lesion using the CT-guided barium marking technique. During brachytherapy, an applicator with a dummy source was inserted under fluoroscopic guidance up to the marker. A radioactive source was subsequently delivered. CT-assisted transbronchial brachytherapy allows radiation to be delivered from inside a lesion. This minimizes radiation damage to non-cancerous tissue and offers distinct advantages over conventional radiation techniques.

+ For reprints and all correspondence: Toshiaki Kobayashi, Endoscopy Division, National Cancer Center Hospital, 1–1, Tsukiji 5-chome, Chuo-ku, Tokyo 104-0045, JapanAbbreviations: CT, computed tomography; HDR, high dose rate; TBAC, transbronchial aspiration cytology


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