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Japanese Journal of Clinical Oncology 30:196-203 (2000)
© 2000 Foundation for Promotion of Cancer Research

Inflammatory Pseudotumor of the Spleen: A Case Report

Hirofumi Noguchi1, Hidenori Kondo1, Masami Kondo1, Misaki Shiraiwa2 and Yasumasa Monobe3,+

1Department of Surgery, Kondo Hospital, Okayama, 2Department of Radiology, Ochiai Hospital, Okayama and 3Department of Pathology, Kawasaki Hospital, Okayama, Japan

We report on an inflammatory pseudotumor of the spleen. A 72-year-old woman visited our hospital complaining of nausea. Physical examination and laboratory investigations were unremarkable. Ultrasonography, computed tomography, magnetic resonance imaging and angiography showed a hypovascular splenic mass measurinsg about 5 cm in diameter with a calcification in the center of the lesion. Splenectomy was performed. The removed spleen, weighing 145 g, contained a tan-white, circumscribed mass, measuring 6.2 x 5.5 x 5.3 cm. Histologically, the splenic mass was composed of an admixture of inflammatory cellular elements, predominantly plasma cells and lymphocytes with hyalinization, fibrosis, lymph follicles and multinuclear giant cells, suggestive of a inflammatory pseudotumor. The patient is currently alive and asymptomatic, 24 months after surgery. Inflammatory pseudotumors of the spleen are extremely rare and only 39 cases have been reported in the medical literature.

+ For reprints and all correspondence: Hirofumi Noguchi, First Department of Surgery, Okayama University Medical School, 2–5–1 Shikatacho, Okayama 700-8558, Japan


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