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Japanese Journal of Clinical Oncology 30:221-224 (2000)
© 2000 Foundation for Promotion of Cancer Research

Suicidal Ideation in Cancer Patients with Major Depression

Tatsuo Akechi1,2, Hitoshi Okamura2, Akira Kugaya2,3, Tomohito Nakano2, Tatsuro Nakanishi3,4, Nobuya Akizuki3, Shigeto Yamawaki5 and Yosuke Uchitomi2,+

1Psychiatry Division, National Cancer Center Hospital, Tokyo, 2Psycho-Oncology Division, National Cancer Center Research Institute East, Kashiwa, Chiba, 3Psychiatry Division, National Cancer Center Hospital East, Kashiwa, Chiba, 4Department of Psychiatry, Kashiwa Hospital, Jikei Medical University, Kashiwa, Chiba and 5Department of Psychiatry and Neurosciences, Hiroshima University School of Medicine, Hiroshima, Japan

Background: Major depression is a well-documented risk factor for suicide in cancer patients as well as in the general population. However, there are no data explaining why some cancer patients suffering from major depression have suicidal ideation whereas others with the same disorder do not.

Methods: We investigated the background differences between cancer patients suffering from major depression with and without suicidal ideation by analyzing consultation data on patients referred to the Psychiatry Division, National Cancer Center Hospital, Japan.

Results: Univariate analysis showed that poor performance status, advanced stage and severe depression were the risk factors for suicidal ideation in these depressive cancer patients. Multivariate logistic regression analysis indicated that older age and severe depression are the final significant risk factors.

Conclusion: These preliminary findings suggest that severe major depression may be an important indicator of suicidal ideation among cancer patients, that patients’ age should be given greater attention and that closer monitoring and more intensive intervention against major depression may be needed.

+ For reprints and all correspondence: Yosuke Uchitomi, Psycho-Oncology Division, National Cancer Center Research Institute East, 6–5–1 Kashiwanoha, Kashiwa 277-8577, Japan. E-mail: yuchitom@east.ncc.go.jp


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