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Japanese Journal of Clinical Oncology 30:276-278 (2000)
© 2000 Foundation for Promotion of Cancer Research

Venous Gangrene in a Patient with Adenocarcinoma of the Lung

Muh-Hwa Yang, Frank S. Fan, Po-Min Chen, Jin-Hwang Liu, Tzeon-Jye Chiou, Wei-Shu Wang and Chueh-Chuan Yen+

Section of Medical Oncology, Department of Medicine, Taipei Veterans General Hospital and National Yang-Ming University, Taipei, Taiwan

Cancer-related thromboembolism is a severe but not uncommon paraneoplastic syndrome in mucinous cancer patients. However, cancer-induced venous gangrene is extremely rare and has never been reported in the English literature. Here, we present a case of lung cancer complicated with venous gangrene of the left foot. An elevated serum anticardiolipin level was detected during hospitalization, but the patient’s clinical condition stabilized after heparinization. We suggest that in cancer patients, an elevated serum anticardiolipin antibody level might be a warning sign of an impending thrombotic event and that low-molecular-weight heparin is a sensible choice in treating this kind of cancer-related thromboembolism.

+ For reprints and all correspondence: Frank S. Fan, Section of Medical Oncology, Department of Medicine, Taipei Veterans General Hospital, No. 201, Sect. 2, Shih-Pai Road, Taipei 11217, Taiwan E-mail: sfan@vghtpe.gov.tw


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