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Japanese Journal of Clinical Oncology 30:310-312 (2000)
© 2000 Foundation for Promotion of Cancer Research

Essential Thrombocythemia Transformed to Acute Myelogenous Leukemia with t(3;17)(p24; q12), del(5)(q13q34) After Treatment with Carboquone and Hydroxyurea

Masahiko Tabata1, Shigehiko Imagawa2, Takahisa Tarumoto1, Ken Ohmine1, Kiyohiko Hatake1, Yasusada Miura1 and Keiya Ozawa1,+

1Department of Hematology, Jichi Medical School, Tochigi and 2Division of Hematology, Institute of Clinical Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan

In 1991, a 52-year-old woman was diagnosed as having essential thrombocythemia (ET). She was doing well with continuous medication with carboquone (CQ) and subsequently hydroxy­urea (HU). However, substantial leukocytosis with leukemic blast cells, anemia and thrombocytopenia developed in 1996. Analysis of peripheral blood showed 4.4 x 103/µl white blood cells with 82% of leukemic blast cells. These blasts showed negative staining with myeloperoxi­dase by immunostaining, but the myeloperoxidase was positive by electron microscopic analysis. Cytogenetic analysis of bone marrow cells revealed a t(3;17)(p24; q12), del(5)(q13q34). On the basis of these findings, the leukemic blast cells were classified as acute myelogenous leukemia (AML: M0) in the FAB classification. The causative agent, CQ and HU in secondary leukemia from ET and chromosomal abnormality related to ET blastic crisis (BC) are discussed.

+ For reprints and all correspondence: Shigehiko Imagawa, Division of Hematology, Institute of Clinical Medicine, University of Tsukuba, Tsukuba, Ibaraki 305-8575, Japan. E-mail: simagawa@md.tsukuba.ac.jp Abbreviations: ET, essential thrombocythemia; CQ, carboquone; HU, hydroxyurea; AML, acute myelogenous leukemia; BC, blastic crisis; MPD, myeloproliferative disorders; PV, polycythemia vera; CML, chronic myelocytic leukemia


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