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Japanese Journal of Clinical Oncology 30:362-365 (2000)
© 2000 Foundation for Promotion of Cancer Research

Chronic Neutrophilic Leukemia with Acute Myeloblastic Transformation

Kensaku Katsuki1, Kenji Shinohara1, Koumei Takeda1, Kouichi Ariyoshi1, Tetsuya Yamada1, Naoko Kameda1, Toru Takahashi1, Ryohei Nawata1, Shoichiro Shibata2, Yoshinobu Asano2 and Seiichi Okamura2

1Division of Hematology, Department of Medicine, Yamaguchi Prefecture Central Hospital, Hofu and 2First Department of Internal Medicine, Faculty of Medicine, Kyushu University, Fukuoka, Japan,+

We report a rare case of chronic neutrophilic leukemia (CNL) which terminated in acute myeloblastic transformation 3 years after the onset of the disease. The increased leukocytes were mainly neutrophils at various maturational stages until 1 month before transformation without dysplastic hematopoietic cells or other myeloproliferative disorders. Repeated analyses for the Philadelphia chromosome (Ph1), rearrangement of the BCR gene or chimeric BCR/ABL mRNA, major, minor and µ, were negative. Genomic analysis of granulocyte colony-stimulating factor (G-CSF) receptor did not reveal any abnormality. The clinical manifestations were characterized by hyperleukocyte syndrome with respiratory distress and ischemic legs with gangrene.

+ For reprints and all correspondence: Kenji Shinohara, Division of Hematology, Department of Medicine, Yamaguchi Prefecture Central Hospital, Hofu 747-8511, JapanAbbreviations: CNL, chronic neutrophilic leukemia; Ph1, Philadelphia chromosome; CML, chronic myeloid leukemia; CMMoL, chronic myelomonocytic leukemia; MDS, myelodysplastic syndrome; BCR, break point cluster region; RT-PCR, reverse transcription polyemerase chain reaction; G-CSF, granulocyte colony-stimulating factor; SSCP, single strand conformation polymorphism


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