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Japanese Journal of Clinical Oncology 31:514-516 (2001)
© 2001 Foundation for Promotion of Cancer Research

A Case of Multiple Atypical Adenomatous Hyperplasia of the Lung Detected by Computed Tomography

Hiroaki Nomori1, Hirotoshi Horio1, Tsuguo Naruke1, Keiichi Suemasu1, Shojiroh Morinaga2 and Masayuki Noguchi3,+,§

1Department of Thoracic Surgery, Saiseikai Central Hospital, Tokyo, 2Department of Pathology, Jichi Medical School, Tochigi and 3Department of Pathology, Institute of Basic Medical Sciences, University of Tsukuba, Tsukuba, Japan

Multiple atypical adenomatous hyperplasia (AAH) of both lungs in a 72-year-old male, detected by computed tomography, is reported. The lesions of the right lung were resected for diagnosis via video-assisted thoracoscopic surgery (VATS). The resected specimen had 22 AAH lesions up to 10 mm in size. For nine of these lesions, the expressions of carcinoembryonic antigen (CEA), c-erbB-2 oncoprotein and p53 gene product were examined by immunohistochemistry and the loss of heterozygosity (LOH) on chromosomes was investigated by polymerase chain reaction analysis. These lesions showed a variety of expressions for CEA, c-erbB-2 and p53 oncoprotein. Three of the nine lesions showed LOH on chromosome 13q, although this was not exhibited in the largest one. These results indicate that each AAH in this case has independent genetic abnormalities and is multicentric.

+ For reprints and all correspondence: Hiroaki Nomori, Department of Thoracic Surgery, Saiseikai Central Hospital, 1–4–17 Mita, Minato-ku, Tokyo 108-0073, Japan

§ Abbreviations: AAH, atypical adenomatous hyperplasia; BAC, bronchioloalveolar carcinoma; CEA, carcinoembryonic antigen; CT, computed tomography; LOH, loss of heterozygosity; PCR, polymerase chain reaction; VATS, video-assisted thoracoscopic surgery


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Home page
 Ann. Thorac. Surg.Home page
H. Nomori, T. Ohtsuka, T. Naruke, and K. Suemasu
Differentiating between atypical adenomatous hyperplasia and bronchioloalveolar carcinoma using the computed tomography number histogram
Ann. Thorac. Surg., September 1, 2003; 76(3): 867 - 871.
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