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Japanese Journal of Clinical Oncology 31:532-535 (2001)
© 2001 Foundation for Promotion of Cancer Research

Expression of the Protein Gene Product 9.5, PGP9.5, is Correlated with T-status in Non-small Cell Lung Cancer

Hidefumi Sasaki, Haruhiro Yukiue, Satoru Moriyama, Yoshihiro Kobayashi, Yoshiaki Nakashima, Masahiro Kaji, Ichiro Fukai, Masanobu Kiriyama, Yosuke Yamakawa and Yoshitaka Fujii+

Department of Surgery II, Nagoya City University Medical School, Nagoya, Japan

Background: In a tumor, increased deubiquitination of cyclins by a protein gene product gene, PGP9.5, could contribute to the uncontrolled growth of somatic cells that is a hallmark of cancer. We hypothesized that PGP9.5 may be expressed in tumors of patients with non-small cell lung cancer (NSCLC).

Methods: Expression of PGP9.5 messenger RNA was evaluated by reverse transcription polymerase chain reaction (RT-PCR) in 95 non-small cell lung carcinomas and adjacent histological normal lung samples. The data were analyzed with reference to clinicopathological factors.

Results: PGP9.5 transcripts were detected in 18 (12.8%) of the tumor samples, although some of paired normal lung samples showed very weak expression. There was no relationship between PGP9.5 gene expression and age, gender, N-status or pathological subtype. PGP9.5 gene was preferentially expressed in T3/T4 NSCLC (12/41, 29.3%) compared with T1/T2 NSCLC (6/54, 11.1%) (p = 0.0482).

Conclusions: Although the PGP9.5 gene was not expressed in a majority of NSCLC tumors, we suggest that PGP9.5 may correlate with tumor invasion or progression of NSCLC.

+ For reprints and all correspondence: Hidefumi Sasaki, Department of Surgery II, Nagoya City University Medical School, 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya 467-8601, Japan. E-mail: hisasaki@med.nagoya-cu.ac.jp


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