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Japanese Journal of Clinical Oncology 31:557-561 (2001)
© 2001 Foundation for Promotion of Cancer Research

Dermatofibrosarcoma Protuberans Metastasizing to Cavernous Sinuses and Lungs: a Case Report

Faruk Zorlu1, Ferah Yildiz1, Dilek Ertoy2, I. Lale Atahan1 and Esra Erden3,+

Departments of 1Radiation Oncology and 2Pathology, Hacettepe University Faculty of Medicine and 3Department of Pathology, Ankara University Faculty of Medicine, Ankara, Turkey

Dermatofibrosarcoma protuberans (DFSP) is a locally aggressive tumor with a low potential for distant metastases. We report a 22-year-old female patient with a typical cutaneous DFSP who developed five local recurrences followed by left cavernous sinus metastasis at the eighth year and right cavernous sinus and lung metastases at the ninth year. In each local recurrence the tumor showed histological signs of progression as being more cellular, having higher mitotic index and being aggressively invasive through the underlying soft tissues. The histopathological evaluation of the metastatic tumor resected from the left cavernous sinus revealed dedifferentiation from low-grade DFSP to higher grade fibrosarcomatous morphology. Immunohistochemical studies of the primary tumor and also the recurrent and metastatic tumors showed diffuse CD34 positivity in all specimens and p53 positivity was detected in the metastatic tumor resected from left cavernous sinus.

+ For reprints and all correspondence: Ferah Yildiz, Department of Radiation Oncology, Hacettepe University Faculty of Medicine, 06100, Ankara, Turkey. E-mail: fyildiz@excite.com


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