Japanese Journal of Clinical Oncology 31:584-588 (2001)
© 2001 Foundation for Promotion of Cancer Research
Levels of Soluble Intercellular Adhesion Molecule-1 and Total Sialic Acid in Serum of Patients with Laryngeal Cancer
1Department of Biochemistry, School of Medicine, 2Department of Otorhinolaryngology–Head and Neck Surgery and 3Department of Physiology, Atatürk University, Erzurum, Turkey
Background: Adhesion molecules have been implicated in tumor progression. In this study, we aimed to investigate serum soluble intercellular adhesion molecule-1 (sICAM-1) and total sialic acid (TSA) levels in laryngeal carcinoma and correlate their levels with the cancer stage.
Method: The sera from 35 patients with laryngeal cancer (10 at stage II, 12 at stage III and 13 at stage IV) were extracted before treatment. The concentrations of sICAM-1 and TSA were measured by enzyme-linked immunoassay and the thiobarbituric acid method, respectively and compared with those from a healthy control group (n = 34).
Results: Mean serum sICAM-1 and TSA levels were found to be higher in the total patient group (the lowest level belonging to stage II) than in the control group (p < 0.001, control versus total patient group). As the stage of the disease increased, higher levels of sICAM-1 and TSA were determined. The correlations between TSA and sICAM-1 became more significant as the stage of the disease increased (r = 0.67, p < 0.05 in stage II, r = 0.86, p < 0.001 in stage III and r = 0.90, p < 0.001 in stage IV).
Conclusion: These data reveal that the significant correlations between sICAM-1 and TSA in laryngeal cancer, more prominent at advanced stage, might reflect the similar nature of these molecules, which function as adhesion molecules.
+ For reprints and all correspondence: Fatih Akcay, Department of Biochemistry, School of Medicine, Atatürk University, 25240 Erzurum, Turkey. E-mail: fakcay32@hotmail.com
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