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Japanese Journal of Clinical Oncology 31:601-604 (2001)
© 2001 Foundation for Promotion of Cancer Research

Chemotherapy of Thymic Carcinoma: Analysis of Seven Cases and Review of the Literature

Akihiko Kitami, Takashi Suzuki, Yoshito Kamio and Shuichi Suzuki+

Departments of Thoracic and Cardiovascular Surgery, Showa University Fujigaoka Hospital, Yokohama, Japan

Background: Thymic carcinoma has a dismal prognosis compared with thymoma, because most of such tumors have locoregional invasion when diagnosed. Thus the important step in the management of thymic carcinoma is the introduction of systemic chemotherapy. However, as thymic carcinoma is a rare neoplasm, treatment with chemotherapy has not been studied systematically.

Methods: We analyzed seven cases of primary thymic carcinoma, treated with various chemotherapy regimens in our hospital from 1990 to 1999, and carried out a literature review of case reports of thymic carcinoma successfully treated with chemotherapy.

Results: All four cases who received modified ADOC therapy obtained partial responses. Other chemotherapeutic regimens (CHOP-E, PVB) were not effective.

Conclusion: Based on the results of this study and the literature review, we feel that a positive response is obtainable with chemotherapy for thymic carcinoma. Modified ADOC therapy showed consistent efficacy in thymic carcinoma in this study.

+ For reprints and all correspondence: Akihiko Kitami, Department of Thoracic and Cardiovascular Surgery, Showa University Fujigaoka Hospital, 1–30 Aoba-ku, Yokohama 227, Japan. E-mail: kitami.a@showa-university-fujigaoka.gr.jp


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