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Japanese Journal of Clinical Oncology 31:82-85 (2001)
© 2001 Foundation for Promotion of Cancer Research

Nodular Thickening of Interlobar Fissures: an Early Manifestation of Malignant Mesothelioma: A Case Report

Shuji Bandoh1, Jiro Fujita1, Yoko Fukunaga1, Shoji Ohtsuka1, Kentaro Susaki1, Yu Yang1, Shoji Kobayashi2 and Jiro Takahara1,+

1First Department of Internal Medicine and 2Department of Diagnostic Pathology, Kagawa Medical University, Kagawa, Japan

Two men with occupational exposure to asbestos were admitted to our hospital with minute pleural changes on their chest CT image. Conventional computed tomography (CT) scans of the chest showed slightly thickened interlobar fissures and a small amount of pleural effusion. In addition, high-resolution CT showed small nodular opacities on interlobar fissures. There were no intrapulmonary mass shadows, pleural plaques or other extrapulmonary mass shadows. These roentgenographical findings were very similar to each other. Hyarulonic acid values obtained from their pleural fluid were extremely high. Finally, we diagnosed them as having malignant mesothelioma using an immunocytochemical technique and electronmicroscopy. We conclude that HRCT is helpful in the diagnosis of malignant mesothelioma, particularly in its early manifestation such as nodular opacities of interlobar fissures.

+ For reprints and all correspondence: Shuji Bandoh, First Department of Internal Medicine, Kagawa Medical University, 1750–1, Miki-cho, Kita-gun, Kagawa, 761-0793, Japan


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