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Japanese Journal of Clinical Oncology 31:142-146 (2001)
© 2001 Foundation for Promotion of Cancer Research

Influence of Thoracic Radiotherapy on Exhaled Nitric Oxide Levels in Patients with Lung Cancer

Masahiko Koizumi1, Hideya Yamazaki2, Kazushige Toyokawa3, Yasuo Yoshioka4, Gen Suzuki4, Masami Ito3, Kunihiko Shinkawa3, Kazumi Nishino3, Yoshiyuki Watanabe3, Takehiro Inoue4, Shuji Ozeki4, Satoko Matsumura4 and Toshihiko Inoue4,+

1Department of Radiation Oncology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Departments of 2Radiology and 4Radiation Oncology, Biomedical Research Center, Osaka University Graduate School of Medicine, Osaka and 3Department of Radiology, Toneyama National Hospital, Osaka, Japan

Background: To determine the physiological role of exhaled nitric oxide (NO) in patients with lung cancer.

Methods: We investigated changes in exhaled NO levels in 29 patients undergoing thoracic radiation therapy with or without chemotherapy. The exhaled NO level was assessed using a chemiluminescence analyzer.

Results: The level of exhaled NO was higher in patients with lung cancer before treatment than in controls. With radiotherapy, the exhaled NO level decreased for patients undergoing 40 Gy irradiation and post-radiotherapy. However, five patients showed elevated levels of exhaled NO three times or more than that before radiotherapy. Three of these patients showed signs of radiation pneumonitis. However, none of the other patients showed signs of radiation pneumonitis (p = 0.002).

Conclusion: Radiation therapy can lower exhaled levels of NO and the levels of exhaled NO may be a useful index for the early prediction of radiation pneumonitis.

+ For reprints and all correspondence: Hideya Yamazaki, Department of Radiology, Osaka University Graduate School of Medicine, 2–2, Yamadaoka, Suita, Osaka 565-0871, Japan. E-mail: hideya10@hotmail.com


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