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Japanese Journal of Clinical Oncology 31:226-230 (2001)
© 2001 Foundation for Promotion of Cancer Research

Mucinous Adenocarcinoma of Bartholin Gland Treated with Radiation Therapy: a Case Report

Tatsuya Ohno1, Takashi Nakano1, Atsuko Abe1, Takaaki Sano2, Yuzuru Niibe1 and Kuniyuki Oka3,+

1Division of Radiation Medicine, National Institute of Radiological Sciences, NIRS, Chiba, 2Second Department of Pathology, Gunma University School of Medicine, Maebashi and 3Department of Pathology, Mito Saiseikai General Hospital, Mito, Ibaraki, Japan

Adenocarcinoma of Bartholin gland is a very rare disease and its molecular pathological features are poorly delineated. A 92-year-old woman with mucinous adenocarcinoma of Bartholin gland with metastasis to the right inguinal lymph node was treated with radiation therapy alone. Despite intensive radiation therapy, the tumor was locally recurrent and the patient died 10 months after radiation therapy. We searched for the presence of human papillomavirus 16 and 18 DNA and the expression of p53 protein, CA19-9, CEA and MIB-1 antigen. Immunohistochemical study showed that mucinous adenocarcinoma of Bartholin gland produced CA19-9 and CEA.

+ For reprints and all correspondence: Tatsuya Ohno, Department of Radiology, Takasaki National Hospital, 36 Takamatsu-Cho, Takasaki, Gunma 370-0829, Japan. E-mail: ohnot@d2.dion.ne.jp


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