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Japanese Journal of Clinical Oncology 31:284-286 (2001)
© 2001 Foundation for Promotion of Cancer Research

Interstitial Pneumonia Possibly Due to a Novel Anticancer Drug, TS-1: First Case Report

Eri Kurakawa, Ikuma Kasuga, Shirou Ishizuka, Tsuyoshi Yoshida, Akira Kunisawa, Kazushige Minemura, Kenta Utsumi and Kazuma Ohyashiki+

First Department of Internal Medicine, Tokyo Medical University, Tokyo, Japan

A newly approved oral fluoropyrimidine, TS-1, is a dihydropyrimide dehydrogenase (DPD)-inhibiting fluoropyrimidine (DIF) drug. We describe a case of interstitial pneumonia probably caused by TS-1. A peripheral blood lymphocytes stimulating test (DLST) with TS-1 demonstrated a substantial positive reaction. So far only three cases of TS-1-induced interstitial pneumonia have been reported but the relationship between interstitial pneumonia and TS-1 was demonstrated only in this case. Considering that interstitial pneumonia has also been reported with 5-FU, it is necessary in the future to clarify which component of this drug is directly related to interstitial pneumonia.

+ For reprints and all correspondence: Ikuma Kasuga, First Department of Internal Medicine, Tokyo Medical University, 7–1 Nishi-shinjuku 6-chome, Shinjuku-ku, Tokyo 160-0023, Japan


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