Japanese Journal of Clinical Oncology 31:337-340 (2001)
© 2001 Foundation for Promotion of Cancer Research
A Case of Lung Metastasis from Endometrial Adenoacanthoma 17 Years after Initial Treatment
1Division of Thoracic Surgery, 2Division of Thoracic Oncology, 3Division of Pathology and 4Division of Gynecology, Kanagawa Cancer Center, Yokohama, Japan
In March 1982, a 60-old woman presented with an International Federation of Gynecology and Obstetrics grade 1, stage Ib endometrial adenoacanthoma, histological subtype of endometrial carcinoma. The patient underwent radical hysterectomy and was followed up for 10 years, without disease. In August 1998, an abnormal shadow in the right lung was suggested on a chest X-ray film at her routine health check-up and she came to our hospital for further evaluation. A thin-section computed tomographic scan of the chest suggested a malignant lung tumor, but the diagnosis remained tentative. Open biopsy was recommended, but the patient refused and was followed up on an outpatient basis. In November 1999, a thin-section computed tomographic scan of the chest revealed a slightly enlarged tumor and laboratory examination showed a high serum progastrin-releasing peptide concentration of 90.7 pg/ml. We performed partial resection of right upper lobe with video-assisted thoracic surgery. Pathological examination confirmed the lung tumor had metastasized from endometrial adenoacanthoma. Immunohistochemical stainings of estrogen receptor and progesterone receptor were positive both in the primary and lung tumor, only in the component of adenocarcinoma. After surgery, the serum progastrin-releasing peptide concentration remained unchanged. The patient is currently alive and free of disease.
+ For reprints and all correspondence: Hiroyuki Ito, Division of Thoracic Surgery, Kanagawa Cancer Center, 1–1–2 Nakao, Asahi-ku, Yokohama 241-0815, Japan. E-mail: JZA01742@nifty.com