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Japanese Journal of Clinical Oncology 31:346-348 (2001)
© 2001 Foundation for Promotion of Cancer Research

DNA Variants of BAT-25 in Japanese, a Locus Frequently Used for Analysis of Microsatellite Instability

Akira Ichikawa1, Kokichi Sugano1,2 and Shin Fujita3,+

1Oncogene Research Unit/Cancer Prevention Unit, Tochigi Cancer Center, Tochigi, 2Genetic Counseling Clinic, National Cancer Center Hospital, Tokyo and 3Department of Surgery, National Cancer Center Hospital, Tokyo, Japan

BAT-25 is a DNA marker, intragenic to the c-kit protooncogene, assigned to 4q12, containing a polythymine tract, mostly repeats of 25 poly(T) (T25). The BAT-25 locus is frequently used in the analysis of microsatellite instability (MSI) in cancer tissues. The number of poly(T) repeats at BAT-25 is reported to be quasi-monomorphic and this property permits the easy identification of the MSI status. We report DNA variants of BAT-25, in one patient with hereditary nonpolyposis colorectal cancer presenting T21 and T25 alleles and another carrying T18 and T25 alleles in the analysis of 100 normal Japanese donors. Observed allelic frequencies were 0.5% for both T21 and T18 alleles. So far, DNA variants of BAT-25 locus have been reported in African Americans with relatively high frequencies, but not in Japanese.

+ For reprints and all correspondence: Kokichi Sugano, Oncogene Research Unit/Cancer Prevention Unit, Tochigi Cancer Center Research Institute, 4–9 Yohnan 13-chome, Utsunomiya, Tochigi 320-0834, Japan. E-mail: ksugano@tcc.pref.tochigi.jp


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