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Japanese Journal of Clinical Oncology 31:428-431 (2001)
© 2001 Foundation for Promotion of Cancer Research

Expression of the cdc25B mRNA Correlated with that of N-myc in Neuroblastoma

Yoko Sato, Hidefumi Sasaki, Satoshi Kondo, Ichiro Fukai, Masanobu Kiriyama, Yosuke Yamakawa and Yoshitaka Fujii+

Department of Surgery II, Nagoya City University Medical School, Nagoya, Japan

Background: Neuroblastoma is one of the most common solid tumors in early childhood. Overexpression of the proto-oncogene N-myc has been reported to be correlated with more malignant course of the disease. cdc25B is reported to be a target of myc and elevated in several malignant cells and tissues.

Methods: Expression of cdc25B and N-myc messenger RNAs were evaluated by real-time reverse transcription polymerase chain reaction (RT-PCR) assay in 20 tumor samples from neuroblastoma using LightCycler. The data were analyzed with reference to clinicopathological factors. Immunohistochemistry for cdc25B was also performed.

Results: There was no significant difference in the cdc25B expression between patient groups according to age, gender and clinical stage. The cdc25B mRNA expression levels were significantly correlated with N-myc mRNA levels (y = –0.445 + 20.577x, p < 0.0001).

Conclusion: We could not establish the clinical significance to determine the cdc25B mRNA level from neuroblastoma. However, we suggest that cdc25B may play an active role as a target of N-myc in neuroblastoma, although the biological function of cdc25B in neuroblastoma remains to be clarified.

+ For reprints and all correspondence: Hidefumi Sasaki, Department of Surgery II, Nagoya City University Medical School, Kawasumi 1, Mizuho-cho, Mizuho-ku, Nagoya, 467-8601, Japan. E-mail: hisasaki@med.nagoya-cu.ac.jp


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