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Japanese Journal of Clinical Oncology 31:454-458 (2001)
© 2001 Foundation for Promotion of Cancer Research

Spontaneous Regression of Hepatocellular Carcinoma with Multiple Lung Metastases: a Case Report

Masafumi Ikeda, Shuichi Okada, Hideki Ueno, Takuji Okusaka and Hitoshi Kuriyama+

Hepatobiliary and Pancreatic Oncology Division, National Cancer Center Hospital, Tokyo, Japan

Spontaneous regression of hepatocellular carcinoma is an extraordinarily unusual phenomenon. We present here a case of a 75-year-old man in whom multiple lung metastases of hepatocellular carcinoma regressed spontaneously. He underwent systemic chemotherapy for hepatocellular carcinoma with multiple lung metastases. However, the chemotherapy was not effective and he was therefore followed up without any anticancer treatments in an outpatient clinic. Four months later, multiple lung nodules regressed dramatically and the serum {alpha}-fetoprotein level decreased markedly. After an 8-month period of the regression, however, intrahepatic lesions gradually enlarged, although multiple lung metastatic lesions remained regressed. The mechanisms underlying this intriguing phenomenon remain unknown.

+ For reprints and all correspondence: Shuichi Okada, Hepatobiliary and Pancreatic Oncology Division, National Cancer Center Hospital, 1–1 Tsukiji 5-chome, Chuo-ku, Tokyo 104-0045, Japan. E-mail: sokada@ncc.go.jp


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