Japanese Journal of Clinical Oncology 32:398-402 (2002)
© 2002 Foundation for Promotion of Cancer Research
Significant Reduction in Breast Cancer Risk for Japanese Women with Interleukin 1B –31 CT/TT Relative to CC Genotype
1 Department of Neurology, School of Medicine, São Paulo University, São Paulo, Brazil and 2 Department of Breast Surgery, 3 Division of Epidemiology and Prevention and 4 Department of Clinical Laboratories, Aichi Cancer Center, Nagoya, Japan
Objective: The present case-control study aimed to examine the associations between breast cancer risk and three functional polymorphisms (Interleukin (IL) –1A C-889T, IL-1B C-31T and IL-1RN 86-bp variable number tandem repeat) related to expression of IL-1ß, which combines estrogen receptor.
Methods: Cases were 231 patients with breast cancer who had been diagnosed 1 month to 6 years before their enrollment in 1999–2000 at Aichi Cancer Center Hospital. Controls were 186 non-cancer outpatients recruited during the same period at the digestive tract, breast surgery and gynecology clinics.
Results: There were no differences in the genotype distributions of the IL-1A and IL-1RN polymorphisms, but individuals harboring a IL-1B C-31T T allele (high expression allele) were less frequent among cases (74.3%) than among controls (84.9%). The age-adjusted odds ratio (OR) relative to CC genotype was 0.52 (95% confidence interval, 0.30–0.88) for CT genotype, 0.58 (0.32–1.02) for TT genotype and 0.54 (0.33–0.90) for CT/TT genotype. Subgroup analysis showed that the preventive effect was significantly stronger for postmenopausal women than for premenopausal women (interaction 0.30, 0.11–0.84).
Conclusions: Although this is the first report on the association between breast cancer risk and IL-1B C-31T, the observed association seems plausible in a biological sense.
+ For reprints and all correspondence: Nobuyuki Hamajima, Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, 1–1 Kanokoden, Chikusa-ku, Nagoya 464-8681, Japan. E-mail: nhamajim@aichi-cc.jp
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