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Japanese Journal of Clinical Oncology 32:477-479 (2002)
© 2002 Foundation for Promotion of Cancer Research

Amifostine-induced Toxic Epidermal Necrolysis during Radiotherapy: a Case Report

Ayse Nur Demiral1, Özlem Yerebakan2, Vildan Simsir1 and Erkan Alpsoy2,+

Departments of 1 Radiation Oncology and 2 Dermatology, Akdeniz University Medical School, Antalya, Turkey

Amifostine is a phosphorylated aminothiol prodrug that can selectively protect normal tissues against the toxic effects of chemotherapy and radiotherapy. In clinical use amifostine is well tolerated and may rarely cause allergic reactions. Stevens–Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are two closely related entities that present with severe acute mucocutaneous reactions most often triggered by drugs. There are only two case reports related to the use of amifostine during radiotherapy, one case with SJS and the other with SJS–TEN overlap.. In this paper, a case with amifostine-induced TEN during radiotherapy is presented.

+ For reprints and all correspondence: Ayse Nur Demiral, Oyak Sitesi A-5 Blok No: 18, 35350 Üçkuyular IZMIR, Turkey.


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