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Japanese Journal of Clinical Oncology 32:546-549 (2002)
© 2002 Foundation for Promotion of Cancer Research

Enteropathy-type T-cell Lymphoma Showing Repeated Small Bowel Rupture and Refractoriness to Chemotherapy: a Case Report

Itaru Kataoka1, Fumitou Arima1, Junko Nishimoto1, Takashi Watanabe1, Yukio Kobayashi1, Ryuji Tamura2, Seiichiro Yamamoto2, Yoshihiro Matsuno3, Tadakazu Shimoda3 and Kensei Tobinai1,+

1 Hematology Division, 2 Colorectal Surgery Division and 3 Clinical Laboratory Division, National Cancer Center Hospital, Tokyo, Japan

The majority of gastrointestinal lymphomas arise in the stomach, whereas lymphomas occurring in the intestine are relatively rare and a limited fraction of them show the T-cell phenotype with clinical manifestations similar to de novo celiac disease. Enteropathy-type T-cell lymphoma is extremely rare in Japan, presumably owing to the very low incidence of celiac disease among the Japanese population. Here, we report a 66-year-old Japanese male who was diagnosed as having enteropathy-type T-cell lymphoma preceded by diarrhea and intermittent bloody stool for over 1 year. He was admitted to our hospital as an emergency case because of panperitonitis due to intestinal perforation. After immediate partial small-bowel resection, cyclophosphamide, doxorubicin, vincristine and prednisone (CHOP) chemotherapy was started. However, the disease was highly refractory and was exacerbated with leukemic transformation. Subsequent salvage chemotherapy could not be completed because of the formation of spontaneous jejuno-abdominal fistula, followed by fatal septic shock. Particular attention should be paid to the peculiar clinical manifestations of enteropathy-type T-cell lymphoma such as malnutrition, frequent intestinal perforation and refractoriness to chemotherapy.

+ For reprints and all correspondence: Kensei Tobinai, Hematology Division, National Cancer Center Hospital, 5–1–1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan. E-mail: ktobinai@ncc.go.jp


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