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Japanese Journal of Clinical Oncology 32:85-89 (2002)
© 2002 Foundation for Promotion of Cancer Research

ßIGH3, a TGF-ß Inducible Gene, is Overexpressed in Lung Cancer

Hidefumi Sasaki, Yoshihiro Kobayashi, Yoshiaki Nakashima, Satoru Moriyama, Haruhiro Yukiue, Masahiro Kaji, Masanobu Kiriyama, Ichiro Fukai, Yosuke Yamakawa and Yoshitaka Fujii+

Department of Surgery II, Nagoya City University Medical School, Nagoya, Japan

Background: Transforming growth factor-ß (TGF-ß) is capable of affecting the proliferation of many cell types. ßIGH3, TGF-ß inducible gene, was originally isolated from lung adenocarcinoma cell line (A549). We have hypothesized that ßIGH3 mRNA levels could be predictors of the development and invasion of lung cancer.

Methods: The study included 71 lung cancer cases. The ßIGH3 mRNA levels were quantified by real time reverse transcription polymerase chain reaction (RT-PCR) using LightCycler.

Results: The ßIGH3 mRNA levels were elevated in tumor tissues from lung cancer (1.058 ± 1.212) compared with non-malignant lung tissues (0.304 ± 0.159) (p = 0.0001). No significant difference in ßIGH3 mRNA levels was found among gender, age, pathological subtype and lymph node metastasis. The ßIGH3 mRNA levels were elevated in tumor tissues from T4 lung cancer (1.425 ± 1.470) compared with those from T1 lung cancer (0.702 ± 0.655) (p = 0.05) and T2 lung cancer (0.736 ± 0.734) (p = 0.044).

Conclusion: Using the LightCycler RT-PCR assay, the determination of ßIGH3 mRNA level might provide a potential marker for the aggressiveness of lung cancer. However, further studies and a longer follow-up are needed to confirm the impact of ßIGH3 on the biological behavior of the tumor.

+ For reprints and all correspondence: Hidefumi Sasaki, Department of Surgery II, Nagoya City University Medical School, 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya 467-8601, Japan. E-mail: hisasaki@med.nagoya-cu.ac.jp


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